NSC23005 sodium

• CAT Number: I002332
• CAS Number: 1796596-46-7
• Molecular Formula: C13H16NNaO4S
• Molecular Weight: 305.33
• Purity: ≥95%
• Target: 5.21 nM (p18INK4C)[1]
• Solubility: DMSO: ≤ 6.4 mg/mL (Need ultrasonic)
• Storage: -20°C

NSC23005 sodium (CAT: I002332) is a novel and potent inhibitor of p18, a protein involved in regulating the self-renewal and proliferation of Hematopoietic Stem Cells (HSCs). NSC23005 sodium has demonstrated efficacy in promoting the expansion of HSCs in both murine and human models. It exhibits an effective dose of 50% (ED50) of 5.21 nM, indicating its high potency. The ability of NSC23005 sodium to enhance HSC expansion suggests its potential application in stem cell therapies and regenerative medicine.

Reference

[1]. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.