For research use only. Not for therapeutic Use.
NSC232003 (Cat No.: I013204) is a potent inhibitor of UHRF1 (Ubiquitin-like with Ph.D. and RING Finger Domains 1) with the ability to permeate cell membranes. This compound is highly effective in inhibiting DNA methylation processes and disrupts the interaction between DNMT1 (DNA Methyltransferase 1) and UHRF1. This disruption has implications for epigenetic regulation and the potential treatment of conditions associated with abnormal DNA methylation patterns.
| Catalog Number | I013204 |
| CAS Number | 1905453-18-0 |
| Molecular Formula | C₆H₇N₃O₃ |
| Purity | ≥95% |
| Target | E1/E2/E3 Enzyme |
| Solubility | H2O: 17 mg/mL (Need ultrasonic and warming) |
| Storage | Store at -20°C |
| IUPAC Name | (5Z)-5-[1-(hydroxyamino)ethylidene]pyrimidine-2,4-dione |
| InChI | InChI=1S/C6H7N3O3/c1-3(9-12)4-2-7-6(11)8-5(4)10/h2,9,12H,1H3,(H,8,10,11)/b4-3- |
| InChIKey | IXSSYZRLNVZFMP-ARJAWSKDSA-N |
| SMILES | CC(=C1C=NC(=O)NC1=O)NO |
| Reference | [1]. Myrianthopoulos V, et al. Tandem virtual screening targeting the SRA domain of UHRF1 identifies a novel chemical tool modulating DNA methylation. Eur J Med Chem. 2016 May 23;114:390-6. |
