For research use only. Not for therapeutic Use.
NSC243928 mesylate is a human lymphocyte antigen 6 (LY6) binder, which also acts as an inhibitor of cell growth and has anticancer activity[1].
NSC243928 mesylate (2 μM, 24 h) induced cell death in MDA-MB-231 control cells and showed an increase in cell viability in LY6K knockdown cells, thus suggesting that NSC243928 may induce cell death through the LY6K pathway[1].
NSC243928 mesylate inhibits MDA-MB-231, Hs-578-T, BT-549 and OVCAR-8 cells with the IC50 values of 5.683 μM, 7.309 μM, 7.954 μM and 4.167 μM, respectively[1].
| Catalog Number | I042027 |
| CAS Number | 59988-01-1 |
| Synonyms | N-[4-(acridin-9-ylamino)-3-methoxyphenyl]ethanesulfonamide;methanesulfonic acid |
| Molecular Formula | C23H25N3O6S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H21N3O3S.CH4O3S/c1-3-29(26,27)25-15-12-13-20(21(14-15)28-2)24-22-16-8-4-6-10-18(16)23-19-11-7-5-9-17(19)22;1-5(2,3)4/h4-14,25H,3H2,1-2H3,(H,23,24);1H3,(H,2,3,4) |
| InChIKey | HPURJIOSFDKFBF-UHFFFAOYSA-N |
| SMILES | CCS(=O)(=O)NC1=CC(=C(C=C1)NC2=C3C=CC=CC3=NC4=CC=CC=C42)OC.CS(=O)(=O)O |
| Reference | [1]. Senyi Benti, et al. Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death. Cancers (Basel). 2020 Feb 22;12(2):509. |
