For research use only. Not for therapeutic Use.
NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].
NSC2805 has WWP2 inhibitory activity with an IC50 of 0.38 μM[1].
NSC2805 shows a significant reduction in activity for all three proteins (WWP2, WWP1 and Nedd4)[1].
NSC2805 can robustly inhibit WWP2-dependent PTEN ubiquitination[1].
| Catalog Number | I033586 |
| CAS Number | 4371-34-0 |
| Synonyms | 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol |
| Molecular Formula | C14H14O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H14O4/c1-7-3-13(17)9(5-11(7)15)10-6-12(16)8(2)4-14(10)18/h3-6,15-18H,1-2H3 |
| InChIKey | DSVRCBOSZSZMRX-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1O)C2=C(C=C(C(=C2)O)C)O)O |
| Reference | [1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680. |
