For research use only. Not for therapeutic Use.
NSC49652 is a reversible, orally active p75 neurotrophin receptor (p75NTR, also known as NGFR, TNFRSF16, and CD271) agonist. NSC49652 targets the transmembrane domain of p75NTR. NSC49652 induces apoptosis and affects the viability of melanoma cells[1].
| Catalog Number | I033627 |
| CAS Number | 908563-68-8 |
| Synonyms | (E)-1-(2-hydroxyphenyl)-3-pyridin-3-ylprop-2-en-1-one |
| Molecular Formula | C14H11NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+ |
| InChIKey | CRWNZUBUBIULHB-BQYQJAHWSA-N |
| SMILES | C1=CC=C(C(=C1)C(=O)C=CC2=CN=CC=C2)O |
| Reference | [1]. Goh ETH, et al. A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth. Cell Chem Biol. 2018 Dec 20;25(12):1485-1494.e5. |
