For research use only. Not for therapeutic Use.
NSC622608 is a V-domain Ig suppressor of T-cell activation (VISTA) ligand with an IC50 value of 4.8 μM[1].
NSC622608 disrupts VISTA-VSIG-3 interaction with an IC50 value of 9.7 ± 0.3 μM[1].
| Catalog Number | I043388 |
| CAS Number | 2593254-90-9 |
| Synonyms | 5-(furan-2-ylmethylimino)-N,N-dimethyl-1,2,4-dithiazol-3-amine;hydrobromide |
| Molecular Formula | C9H12BrN3OS2 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H11N3OS2.BrH/c1-12(2)9-11-8(14-15-9)10-6-7-4-3-5-13-7;/h3-5H,6H2,1-2H3;1H |
| InChIKey | VVZWMEHUXGPOIY-UHFFFAOYSA-N |
| SMILES | CN(C)C1=NC(=NCC2=CC=CO2)SS1.Br |
| Reference | [1]. Gabr MT, et al. Discovery and Optimization of Small-Molecule Ligands for V-Domain Ig Suppressor of T-Cell Activation (VISTA). J Am Chem Soc. 2020 Sep 23;142(38):16194-16198. |
