For research use only. Not for therapeutic Use.
NSC639828 is a potent inhibitor of DNA polymerase α with an IC50 of 70 μM. NSC639828 has high antitumor activity. NSC639828 has the potential for researching cancer disease[1].
| Catalog Number | M114287 |
| CAS Number | 134742-26-0 |
| Synonyms | 2-amino-N-[[4-(5-bromopyrimidin-2-yl)oxy-3-chlorophenyl]carbamoyl]benzamide |
| Molecular Formula | C18H13BrClN5O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H13BrClN5O3/c19-10-8-22-18(23-9-10)28-15-6-5-11(7-13(15)20)24-17(27)25-16(26)12-3-1-2-4-14(12)21/h1-9H,21H2,(H2,24,25,26,27) |
| InChIKey | LRPFTPYFADHGQJ-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C(=C1)C(=O)NC(=O)NC2=CC(=C(C=C2)OC3=NC=C(C=N3)Br)Cl)N |
| Reference | [1]. Abdel-Aziz W, et al. Effect of novel benzoylphenylurea derivatives on DNA polymerase alpha activity using the synthesome-based in vitro model system. Invest New Drugs. 2003;21(4):421-428. |
