For research use only. Not for therapeutic Use.
NSC693868 is a selective inhibitor of CDK1 and CDK5 with IC50s of 600 nM and 400 nM, respectively. NSC693868 less potently inhibits GSK3β with an IC50 of 1 µM) and does not block CDC25 activity. NSC693868 is used to help define the roles of CDK1 and CDK5 in various signaling pathways[1].
| Catalog Number | R032971 |
| CAS Number | 40254-90-8 |
| Synonyms | 2H-pyrazolo[4,3-b]quinoxalin-3-amine |
| Molecular Formula | C9H7N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H7N5/c10-8-7-9(14-13-8)12-6-4-2-1-3-5(6)11-7/h1-4H,(H3,10,12,13,14) |
| InChIKey | DWHVZCLBMTZRQM-UHFFFAOYSA-N |
| SMILES | C1=CC2=NC3=C(NN=C3N=C2C=C1)N |
| Reference | [1]. Ortega MA, et al. Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors. Bioorg Med Chem. 2002 Jul;10(7):2177-84. |
