For research use only. Not for therapeutic Use.
NSC745885 (Cat No.: I016660) is an effective anti-tumor agent that is selectively toxic to a variety of cancer cell lines but not to normal cells. NSC745885 is a potent down-regulator of EZH2 through the proteasomal degradation pathway. NSC745885 provides possibilities for the research of advanced bladder cancer and oral squamous cell carcinoma.
| Catalog Number | I016660 |
| CAS Number | 4219-52-7 |
| Molecular Formula | C₁₄H₆N₂O₂S |
| Purity | ≥95% |
| Target | Epigenetics |
| Storage | Store at -20°C |
| IUPAC Name | naphtho[2,3-g][2,1,3]benzothiadiazole-6,11-dione |
| InChI | InChI=1S/C14H6N2O2S/c17-13-7-3-1-2-4-8(7)14(18)11-9(13)5-6-10-12(11)16-19-15-10/h1-6H |
| InChIKey | SJPXIVLTCBBWKT-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=NSN=C4C=C3 |
| Reference | [1]. Chen YW, et al.A novel compound NSC745885 exerts an anti-tumor effect on tongue cancer SAS cells in vitro and in vivo.PLoS One. 2014 Aug 15;9(8):e104703.<br>[2]. Tang SH, et al. Pharmacologic down-regulation of EZH2 suppresses bladder cancer in vitro and in vivo.Oncotarget. 2014 Nov 15;5(21):10342-55. |
