For research use only. Not for therapeutic Use.
NSC745887 is a DcR3 inhibitor which reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in glioblastoma multiforme (GBM) cells. Moreover, NSC745887 inhibits the proliferation of various cancers by trapping DNA-topoisomerase cleavage.
KEYWORDS: NSC745887 | supplier | DcR3 inhibitor | NSC 745887 | NSC-745887 | CAS [54490-26-5] | TNF-α | DcR3 | Inhibitor | Receptors | Glioblastoma multiforme | GBM | TNFRSF6B | TR6 | M68
| Catalog Number | I033657 |
| CAS Number | 54490-26-5 |
| Molecular Formula | C16H8N2O2 |
| Purity | ≥95% |
| IUPAC Name | naphtho[3,2-f]quinoxaline-7,12-dione |
| InChI | InChI=1S/C16H8N2O2/c19-15-9-3-1-2-4-10(9)16(20)13-11(15)5-6-12-14(13)18-8-7-17-12/h1-8H |
| SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=NC=CN=C4C=C3 |
| Reference | LY Fann et al. Identification and preclinical evaluation of the small molecule, NSC745887, for treating glioblastomas via suppressing DcR3-associated signaling pathways. Oncotarget. 2017 Dec 27;9(15):11922-11937. |
