For research use only. Not for therapeutic Use.
NSC756093 is a potent inhibitor of the GBP1:PIM1 interaction. NSC756093 can potentially revert resistance to paclitaxel. NSC756093 can be used for ovarian cancer research[1].
| Catalog Number | I012336 |
| CAS Number | 1629908-92-4 |
| Synonyms | 4-(2-hydroxyethyl)-6-methoxy-9-phenyl-3,9-dihydrofuro[3,4-b]quinolin-1-one |
| Molecular Formula | C20H19NO4 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H19NO4/c1-24-14-7-8-15-16(11-14)21(9-10-22)17-12-25-20(23)19(17)18(15)13-5-3-2-4-6-13/h2-8,11,18,22H,9-10,12H2,1H3 |
| InChIKey | SMEJQLRLHKWIFV-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)C(C3=C(N2CCO)COC3=O)C4=CC=CC=C4 |
| Reference | [1]. Andreoli M, et al. Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells. J Med Chem. 2014 Oct 9;57(19):7916-32. |
