For research use only. Not for therapeutic Use.
NT1-014B is a potent NT1-lipidoid encapsulated AmB (amphotericin B). NT1-014B dopes the NT-lipidoids into BBB-impermeable lipid nanoparticles (LNPs) gave the LNPs the ability to cross the BBB. NT1-014B enhances brain delivery through intravenous injection[1].
| Catalog Number | I041795 |
| CAS Number | 2739805-64-0 |
| Synonyms | 2-(decyldisulfanyl)ethyl 3-[[3-[2-(decyldisulfanyl)ethoxy]-3-oxopropyl]-[2-(1H-indol-3-yl)ethyl]amino]propanoate |
| Molecular Formula | C40H68N2O4S4 |
| Purity | ≥95% |
| InChI | InChI=1S/C40H68N2O4S4/c1-3-5-7-9-11-13-15-19-31-47-49-33-29-45-39(43)24-27-42(26-23-36-35-41-38-22-18-17-21-37(36)38)28-25-40(44)46-30-34-50-48-32-20-16-14-12-10-8-6-4-2/h17-18,21-22,35,41H,3-16,19-20,23-34H2,1-2H3 |
| InChIKey | LBQUNMQRWYTNHB-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCSSCCOC(=O)CCN(CCC1=CNC2=CC=CC=C21)CCC(=O)OCCSSCCCCCCCCCC |
| Reference | [1]. Ma F, et al. Neurotransmitter-derived lipidoids (NT-lipidoids) for enhanced brain delivery through intravenous injection. Sci Adv. 2020 Jul 24;6(30):eabb4429. |
