For research use only. Not for therapeutic Use.
NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2].
NT157 (0.3-3 μM; 72 hours) shows a strong dose-dependent inhibition of growth in all cell lines tested, and the IC50 s ranges from 0.3 to 0.8 μM[1].
NT157 (1-3 μM; 24 hours) induces cell cycle arrest in MG-63 and U-2OS OS cells[1].
NT157 (1-3 μM; 48 hours) downregulates the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells[1].
NT157 (50 mg/kg; i.p.; three times per week for 6 weeks) significantly delayed tumor growth in castrated mice bearing LNCaP xenografts [3].
| Catalog Number | I001485 |
| CAS Number | 1384426-12-3 |
| Synonyms | (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-[(3,4,5-trihydroxyphenyl)methyl]prop-2-enethioamide |
| Molecular Formula | C16H14BrNO5S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H14BrNO5S/c17-10-3-8(4-11(19)15(10)22)1-2-14(24)18-7-9-5-12(20)16(23)13(21)6-9/h1-6,19-23H,7H2,(H,18,24)/b2-1+ |
| InChIKey | NIPUPOUEGOSAAO-OWOJBTEDSA-N |
| SMILES | C1=C(C=C(C(=C1O)O)O)CNC(=S)C=CC2=CC(=C(C(=C2)Br)O)O |
| Reference | [1]. Downregulated the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells. [2]. Flashner-Abramson E, et al. Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling. Oncogene. 2016 May 19;35(20):2675-80. [3]. Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 Dec;13(12):2827-39. [4]. Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat Commun. 2018 Jul 4;9(1):2611. |
