For research use only. Not for therapeutic Use.
NT160 is a highly potent class-IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 can be used for the research of central nervous system diseases[1].
NT160 has affinity for class-IIa HDAC4 isoform with an IC50 value of 0.046 μM[1].
NT160 exhibites a remarkably high inhibition against HDAC4, HDAC5, HDAC7 and HDAC9 with IC50 values of 0.08 nM, 1.2 nM, 1.0 nM and0.9 nM, respectively[1].
| Catalog Number | I041190 |
| CAS Number | 1418293-40-9 |
| Synonyms | N-[(2R)-1-[benzyl(methyl)amino]propan-2-yl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide |
| Molecular Formula | C21H21F3N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H21F3N4O2/c1-14(12-28(2)13-15-6-4-3-5-7-15)25-19(29)17-10-8-16(9-11-17)18-26-20(30-27-18)21(22,23)24/h3-11,14H,12-13H2,1-2H3,(H,25,29)/t14-/m1/s1 |
| InChIKey | RESDVUQVZOJNSO-CQSZACIVSA-N |
| SMILES | CC(CN(C)CC1=CC=CC=C1)NC(=O)C2=CC=C(C=C2)C3=NOC(=N3)C(F)(F)F |
| Reference | [1]. Turkman N, et al. Design, synthesis, biochemical evaluation, radiolabeling and in vivo imaging with high affinity class-IIa histone deacetylase inhibitor for molecular imaging and targeted therapy. Eur J Med Chem. 2022;228:114011. |
