For research use only. Not for therapeutic Use.
NTPAN-MI is a fluorescent probe. NTPAN-MI is selectively activated upon labeling unfolded proteins with exposed thiols, thereby reporting on the extent of proteostasis[1].
| Catalog Number | I040122 |
| CAS Number | 2411398-95-1 |
| Synonyms | 3,3-bis[4-(dimethylamino)phenyl]-2-[4-(2,5-dioxopyrrol-1-yl)phenyl]prop-2-enenitrile |
| Molecular Formula | C29H26N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C29H26N4O2/c1-31(2)23-11-7-21(8-12-23)29(22-9-13-24(14-10-22)32(3)4)26(19-30)20-5-15-25(16-6-20)33-27(34)17-18-28(33)35/h5-18H,1-4H3 |
| InChIKey | CGOIFUPZTOUIMX-UHFFFAOYSA-N |
| SMILES | CN(C)C1=CC=C(C=C1)C(=C(C#N)C2=CC=C(C=C2)N3C(=O)C=CC3=O)C4=CC=C(C=C4)N(C)C |
| Reference | [1]. Owyong TC, et al. A Molecular Chameleon for Mapping Subcellular Polarity in an Unfolded Proteome Environment. Angew Chem Int Ed Engl. 2020 Jun 15;59(25):10129-10135. |
