For research use only. Not for therapeutic Use.
NU6300 is a covalent, irreversible and ATP-competitive CDK2 inhibitor with an IC50 value of 0.16 μM. NU6300 can be used for the research of eukaryotic cell cycle- and transcription-related[1].
NU6300 (50 μM; 0-1 hour) covalently modifies and irreversible inhibits CDK2[1].
| Catalog Number | I005772 |
| CAS Number | 2070015-09-5 |
| Synonyms | 6-(cyclohexylmethoxy)-N-(4-ethenylsulfonylphenyl)-7H-purin-2-amine |
| Molecular Formula | C20H23N5O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C20H23N5O3S/c1-2-29(26,27)16-10-8-15(9-11-16)23-20-24-18-17(21-13-22-18)19(25-20)28-12-14-6-4-3-5-7-14/h2,8-11,13-14H,1,3-7,12H2,(H2,21,22,23,24,25) |
| InChIKey | KGWSQGUVJUGIPF-UHFFFAOYSA-N |
| SMILES | C=CS(=O)(=O)C1=CC=C(C=C1)NC2=NC3=C(C(=N2)OCC4CCCCC4)NC=N3 |
| Reference | [1]. Anscombe E, et al. Identification and Characterization of an Irreversible Inhibitor of CDK2. Chem Biol. 2015 Sep 17;22(9):1159-1164. |
