NUC-3373

• CAT Number: I033682
• CAS Number: 1332837-31-6
• Molecular Formula: C29H30F2N4O8P
• Molecular Weight: 631.54
• Purity: 98%
• Synonyms: NUC-3373; NUC 3373; NUC3373
• Target: Thymidylate Synthase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: benzyl (2S)-2-[[[(2R,3S,5R)-5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-naphthalen-1-yloxyphosphoryl]amino]propanoate
• InChI: InChI=1S/C29H29FN3O9P/c1-18(28(36)39-16-19-8-3-2-4-9-19)32-43(38,42-24-13-7-11-20-10-5-6-12-21(20)24)40-17-25-23(34)14-26(41-25)33-15-22(30)27(35)31-29(33)37/h2-13,15,18,23,25-26,34H,14,16-17H2,1H3,(H,32,38)(H,31,35,37)/t18-,23-,25+,26+,43?/m0/s1
• InChIKey: BIOWRMNRHMERIO-ZVAHOJSLSA-N
• SMILES: C[C@@H](C(=O)OCC1=CC=CC=C1)NP(=O)(OC[C@@H]2[C@H](C[C@@H](O2)N3C=C(C(=O)NC3=O)F)O)OC4=CC=CC5=CC=CC=C54

NUC-3373（Cat No.:I033682）is a novel nucleoside analog being developed for the treatment of cancer. It is a prodrug of a cytotoxic metabolite that targets and inhibits cancer cell proliferation by interfering with DNA replication and transcription. NUC-3373 has demonstrated potent antitumor activity in preclinical models, particularly against tumors with deficiencies in DNA repair mechanisms. By incorporating into the cancer cell’s DNA, NUC-3373 causes lethal DNA damage, leading to cell death. It is being investigated in clinical trials for its efficacy in treating various cancers, including solid tumors and hematologic malignancies.