NUC-3373

• CAT Number: I033682
• CAS Number: 1332837-31-6
• Molecular Formula: C29H30F2N4O8P
• Molecular Weight: 631.54
• Purity: 98%
• Synonyms: NUC-3373; NUC 3373; NUC3373
• Target: Thymidylate Synthase
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: L-Alanine, N-(-2'-deoxy-2',2'-difluoro-p-1-naphthalenyl-5'-cytidylyl)-, phenylmethyl ester
• InChI: InChI=1S/C29H30F2N4O8P/c1-18(26(37)41-16-19-8-3-2-4-9-19)34-44(39,40,23-13-7-11-20-10-5-6-12-21(20)23)42-17-22-25(36)29(30,31)27(43-22)35-15-14-24(32)33-28(35)38/h2-15,18,22,25,27,36H,16-17H2,1H3,(H2,32,33,38)(H2,34,39,40)/t18-,22+,25+,27+/m0/s1
• InChIKey: LYMGFDGRLCYHTR-ICIRLHQFSA-N
• SMILES: C[C@@H](C(OCC1=CC=CC=C1)=O)NP(OC[C@@H]2[C@H](C(F)(F)[C@H](N3C(N=C(C=C3)N)=O)O2)O)(O)(C4=C5C=CC=CC5=CC=C4)=O

NUC-3373 is a potent cancel stem cell inhibitor. NUC-3373 has preferential cytotoxic effects on leukemic stem cells (LSCs). In vitro data confirmed that NUC-3373 exerts its cytotoxic activity independently of thymidine kinase in TK-deficient tumor cell lines, and it is resistant to degradative action by catabolic enzymes including TP and DPD.19 In addition, NUC-3373 was found to generate 366- fold higher intracellular levels of the active monophosphate form, FdUMP, in the human colorectal cancer cell line HT29 compared with 5-FU and achieved significantly greater tumor volume reduction than 5-FU in HT29 xenograft studies.