For research use only. Not for therapeutic Use.
NUC-7738, an aryloxy phosphoramidate of 3′-Deoxyadenosine, is a 5′-aryloxy phosphoramidate prodrug of 3′-Deoxyadenosine (3′-dA). NUC-7738 has potent cytotoxic activity against a panel of hematological cancer cell lines. NUC-7738 can be used in research of cancer[1].
NUC-7738 (compound 7a; 0-198 μM; 72 h; CCRF-CEM, HL-60, KG-1, MOLT-4, K562, MV4-11, THP-1, HEL92, NCI-H929, RPMI-8226, Jurkat, Z138, RL, HS445, HepG2, MCF-7, Bx-PC-3, HT29, MIA PaCa-2 and SW620 cells) has anticancer activity and cytotoxic activity against a lineage of leukocytes with LC50 values of ＜30 μM[1].
NUC-7738 (1 μM) has good stability in human hepatocytes with t1/2 value of 48.1 min[1].
NUC-7738 has increased stability in human plasma compared to the parent nucleoside, with no change in plasma concentration up to 4 h[1].
| Catalog Number | I042327 |
| CAS Number | 2348493-39-8 |
| Synonyms | benzyl (2S)-2-[[[(2S,4S,5R)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate |
| Molecular Formula | C26H29N6O7P |
| Purity | ≥95% |
| InChI | InChI=1S/C26H29N6O7P/c1-17(26(34)36-13-18-8-4-2-5-9-18)31-40(35,39-19-10-6-3-7-11-19)37-14-20-12-21(33)25(38-20)32-16-30-22-23(27)28-15-29-24(22)32/h2-11,15-17,20-21,25,33H,12-14H2,1H3,(H,31,35)(H2,27,28,29)/t17-,20-,21-,25+,40?/m0/s1 |
| InChIKey | UDLWWGQHMQIYCV-FELPLCCLSA-N |
| SMILES | CC(C(=O)OCC1=CC=CC=C1)NP(=O)(OCC2CC(C(O2)N3C=NC4=C(N=CN=C43)N)O)OC5=CC=CC=C5 |
| Reference | [1]. Serpi M, et, al. Synthesis and Characterization of NUC-7738, an Aryloxy Phosphoramidate of 3′-Deoxyadenosine, as a Potential Anticancer Agent. J Med Chem. 2022 Dec 8;65(23):15789-15804. |
