NUC-7738

• CAT Number: I042327
• CAS Number: 2348493-39-8
• Molecular Formula: C26H29N6O7P
• Molecular Weight: 568.52
• Purity: ≥95%
• Synonyms: benzyl (2S)-2-[[[(2S,4S,5R)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• IUPAC Name: benzyl (2S)-2-[[[(2S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxyoxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
• InChI: InChI=1S/C26H29N6O7P/c1-17(26(34)36-13-18-8-4-2-5-9-18)31-40(35,39-19-10-6-3-7-11-19)37-14-20-12-21(33)25(38-20)32-16-30-22-23(27)28-15-29-24(22)32/h2-11,15-17,20-21,25,33H,12-14H2,1H3,(H,31,35)(H2,27,28,29)/t17-,20-,21+,25+,40?/m0/s1
• InChIKey: UDLWWGQHMQIYCV-LKKHFEEPSA-N
• SMILES: C[C@@H](C(=O)OCC1=CC=CC=C1)NP(=O)(OC[C@@H]2C[C@H]([C@@H](O2)N3C=NC4=C(N=CN=C43)N)O)OC5=CC=CC=C5

NUC-7738（Cat No.:I042327）is a novel nucleotide analog currently under investigation as a potential cancer treatment. It works by targeting and inhibiting key enzymes involved in DNA replication and repair, disrupting the growth and survival of cancer cells. NUC-7738 is designed to selectively accumulate in tumor cells, enhancing its therapeutic efficacy while minimizing damage to normal tissues. The compound has shown promising preclinical results, particularly in overcoming resistance mechanisms in certain cancers. Ongoing clinical trials aim to assess its safety, effectiveness, and potential as part of combination therapies for various cancer types.