NUCC-0226272

• CAT Number: I040072
• CAS Number: 3004503-12-9
• Molecular Formula: C67H91N9O8S
• Molecular Weight: 1182.56
• Purity: ≥95%
• Synonyms: (2S,4R)-1-[(2S)-2-[[11-[4-[[4-[3-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methylcarbamoyl]-5-[ethyl(oxan-4-yl)amino]-4-methylphenyl]phenyl]methyl]piperazin-1-yl]-11-oxoundecanoyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
• InChI: InChI=1S/C67H91N9O8S/c1-9-75(53-27-33-84-34-28-53)57-37-52(36-55(46(57)4)63(80)69-40-56-44(2)35-45(3)71-64(56)81)50-23-21-49(22-24-50)41-73-29-31-74(32-30-73)60(79)18-16-14-12-10-11-13-15-17-59(78)72-62(67(6,7)8)66(83)76-42-54(77)38-58(76)65(82)68-39-48-19-25-51(26-20-48)61-47(5)70-43-85-61/h19-26,35-37,43,53-54,58,62,77H,9-18,27-34,38-42H2,1-8H3,(H,68,82)(H,69,80)(H,71,81)(H,72,78)/t54-,58+,62-/m1/s1
• InChIKey: GQULETMWOLCBGK-MUSRFAHESA-N
• SMILES: CCN(C1CCOCC1)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C4=CC=C(C=C4)CN5CCN(CC5)C(=O)CCCCCCCCCC(=O)NC(C(=O)N6CC(CC6C(=O)NCC7=CC=C(C=C7)C8=C(N=CS8)C)O)C(C)(C)C

NUCC-0226272 (Cat No.: I040072) is a novel small-molecule inhibitor designed for targeted cancer and inflammation research. It exhibits high specificity and potency in modulating key signaling pathways involved in tumor progression, immune response, and cellular proliferation. NUCC-0226272 is optimized for in vitro and in vivo studies, offering excellent bioavailability and selectivity. This research-grade compound supports drug discovery and mechanistic studies, aiding in the development of innovative therapies for oncology, immunology, and metabolic diseases. Suitable for preclinical evaluations, it accelerates research in precision medicine.

Reference

[1]. Gary E. Schiltz, et al. Substituted 3-amino-5-phenylbenzamide compounds as covalent inhibitors of enhancer zeste homolog 2 (ezh2) and proteolysis-targeting chimeric derivatives thereof (protacs) that induce degradation of ezh2. US20230346953A1.