Nucleoside-Analog-1

• CAT Number: I005275
• CAS Number: 876707-99-2
• Molecular Formula: C9H9N5O5
• Molecular Weight: 267.20
• Purity: ≥95%
• Target: Anti-infection
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (2R,4R,5S,6S)-4-azido-5-hydroxy-4-(hydroxymethyl)-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-10-one
• InChI: InChI=1S/C9H9N5O5/c10-13-12-9(3-15)6(17)5-7(19-9)14-2-1-4(16)11-8(14)18-5/h1-2,5-7,15,17H,3H2/t5-,6-,7+,9+/m0/s1
• InChIKey: HXIRTOCBJXONPW-XZMZPDFPSA-N
• SMILES: C1=CN2[C@H]3[C@H]([C@@H]([C@](O3)(CO)N=[N+]=[N-])O)OC2=NC1=O

Nucleoside-Analog-1（Cat No.:I005275）is a synthetic nucleoside analog designed to interfere with DNA or RNA synthesis, making it a valuable tool in cancer research and antiviral therapy. By mimicking natural nucleosides, it can be incorporated into growing DNA or RNA chains during replication, leading to chain termination or mutations that inhibit cellular proliferation. This mechanism makes Nucleoside-Analog-1 particularly effective against rapidly dividing cells, such as cancer cells or viruses. Its potential therapeutic applications include treatments for viral infections, like hepatitis or HIV, and various cancers, though its efficacy and safety require further clinical study.

Reference

[1]. Smith DB, et al. The design, synthesis, and antiviral activity of 4/’-azidocytidine analogues against hepatitis C virus replication: the discovery of 4/’-azidoarabinocytidine. J Med Chem. 2009 Jan 8;52(1):219-23.
[2]. Smith DB, et al. The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4/’-azidocytidine against hepatitis C virus replication: the discovery of 4/’-azido-2/’-deoxy-2/’-fluorocytidine and 4/’-azido-2/’-dideoxy-2/’,2/’-difluorocytidine. J Med Chem. 2009 May 14;52(9):2971-8.