For research use only. Not for therapeutic Use.
Nucleozin（Cat No.:I003235）is a small-molecule compound with antiviral properties, primarily used in research related to the inhibition of viral replication. It functions by binding to the nucleoprotein of certain viruses, preventing the formation of the ribonucleoprotein complex necessary for the viral RNA replication process. Nucleozin has shown potential as a therapeutic agent against RNA viruses, including influenza, by disrupting the viral life cycle. As a research tool, Nucleozin is valuable for studying viral mechanisms and developing antiviral strategies, especially in the context of pandemic preparedness.
| Catalog Number | I003235 |
| CAS Number | 341001-38-5 |
| Synonyms | [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone |
| Molecular Formula | C21H19ClN4O4 |
| Purity | ≥95% |
| Target | Influenza Virus |
| Solubility | DMSO |
| Storage | Store at -20°C |
| IUPAC Name | [4-(2-chloro-4-nitrophenyl)piperazin-1-yl]-(5-methyl-3-phenyl-1,2-oxazol-4-yl)methanone |
| InChI | InChI=1S/C21H19ClN4O4/c1-14-19(20(23-30-14)15-5-3-2-4-6-15)21(27)25-11-9-24(10-12-25)18-8-7-16(26(28)29)13-17(18)22/h2-8,13H,9-12H2,1H3 |
| InChIKey | OWXBJAPOSQSWAO-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=NO1)C2=CC=CC=C2)C(=O)N3CCN(CC3)C4=C(C=C(C=C4)[N+](=O)[O-])Cl |
| Reference | </br>1:Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites. Pang B, Cheung NN, Zhang W, Dai J, Kao RY, Zhang H, Hao Q.Sci Rep. 2016 Jul 11;6:29684. doi: 10.1038/srep29684. PMID: 27404920 Free PMC Article</br>2:Nucleozin targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection. Amorim MJ, Kao RY, Digard P.J Virol. 2013 Apr;87(8):4694-703. doi: 10.1128/JVI.03123-12. Epub 2013 Feb 13. PMID: 23408618 Free PMC Article |
