For research use only. Not for therapeutic Use.
NucPE1（Cat No.:I013399）is an investigational peptide designed for targeted delivery of therapeutics to the nucleus of cells. It is a type of cell-penetrating peptide (CPP) that facilitates the efficient transport of bioactive molecules, including drugs and nucleic acids, across the cell membrane and into the nucleus. NucPE1 has been studied for its potential in gene therapy and cancer treatment, where it can enhance the delivery of therapeutic agents directly to the nucleus, improving the precision and effectiveness of treatments. Ongoing research aims to evaluate its safety, efficiency, and clinical applicability in various therapeutic areas.
| Catalog Number | I013399 |
| CAS Number | 1404091-23-1 |
| Molecular Formula | C₂₉H₃₀BNO₅ |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | DMSO |
| IUPAC Name | 3'-(ethylamino)-2'-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)spiro[2-benzofuran-3,9'-xanthene]-1-one |
| InChI | InChI=1S/C29H30BNO5/c1-7-31-23-16-25-22(14-17(23)2)29(20-11-9-8-10-19(20)26(32)34-29)21-13-12-18(15-24(21)33-25)30-35-27(3,4)28(5,6)36-30/h8-16,31H,7H2,1-6H3 |
| InChIKey | GHPDUBPWQBBRPG-UHFFFAOYSA-N |
| SMILES | B1(OC(C(O1)(C)C)(C)C)C2=CC3=C(C=C2)C4(C5=CC=CC=C5C(=O)O4)C6=C(O3)C=C(C(=C6)C)NCC |
| Reference | [1]. Stanicka J, et al. NADPH oxidase-generated hydrogen peroxide induces DNA damage in mutant FLT3-expressing leukemia cells. J Biol Chem. 2015 Apr 10;290(15):9348-61. <br>[2]. Dickinson BC, et al. A nuclear-localized fluorescent hydrogen peroxide probe for monitoring sirtuin-mediated oxidative stress responses in vivo. Chem Biol. 2011 Aug 26;18(8):943-8. |
