Nutlin-3

• CAT Number: I002873
• CAS Number: 890090-75-2
• Molecular Formula: C30H30Cl2N4O4
• Molecular Weight: 581.5
• Purity: ≥95%
• Storage: 3 years-20°Cpowder
• SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.

Reference

[1] Vassilev LT, et al. Science, 2004, 303(5659), 844-848.
[2] Thompson T, et al. J Biol Chem, 2004, 279(51), 53015-53022.
[3] Laurie NA, et al. Nature, 2006, 444(7115), 61-66.
[4] Lau LM, et al. Oncogene, 2008, 27(7), 997-1003.
[5] 宮崎, 理樹. Study on p53-MDM2 Interaction Inhibitors as a Novel Anticancer Agent. 2013, Hokkaido University.