Nutlin-3a

• CAT Number: I004542
• CAS Number: 675576-98-4
• Molecular Formula: C30H30Cl2N4O4
• Molecular Weight: 581.49
• Purity: ≥95%
• Synonyms: 4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
• InChI: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1
• InChIKey: BDUHCSBCVGXTJM-WUFINQPMSA-N
• SMILES: CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

Nutlin-3a(CAT: I004542) is a small-molecule inhibitor that specifically targets the interaction between the p53 tumor suppressor protein and MDM2, an oncogenic protein that negatively regulates p53. By preventing this interaction, Nutlin-3a stabilizes and activates p53, leading to the induction of apoptosis and cell cycle arrest in cancer cells. This makes Nutlin-3a a valuable compound in cancer research, particularly for cancers with intact p53 pathways. It has shown promise in preclinical studies as a potential therapeutic for treating various types of cancers, including sarcomas and leukemias. Nutlin-3a is extensively studied for its role in restoring p53 function and promoting tumor suppression.