For research use only. Not for therapeutic Use.
NV-5138 hydrochloride, a leucine analog, is the first selective and orally active brain mTORC1 activator, binding to Sestrin2. NV-5138 hydrochloride is used for antidepressant studies[1][2].
NV-5138 is found to be essentially 100% orally bioavailable with an elimination half-life in plasma of ~ 3 h determined following intravenous and oral dosing in rats[1].?
NV-5138 (160 mg/kg, po, single dose) rapidly increases levels of phospho-mTOR as well as the downstream targets, phospho-p70S6K1, and phosphor-4EB-P1, in synaptosomal preparations of PFC[2].?
NV-5138 (80 mg/kg, po, daily for a total of 7 days) also produces antidepressant effects[2].
| Catalog Number | I045582 |
| CAS Number | 2639392-70-2 |
| Synonyms | (2S)-2-amino-5,5-difluoro-4,4-dimethylpentanoic acid;hydrochloride |
| Molecular Formula | C7H14ClF2NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C7H13F2NO2.ClH/c1-7(2,6(8)9)3-4(10)5(11)12;/h4,6H,3,10H2,1-2H3,(H,11,12);1H/t4-;/m0./s1 |
| InChIKey | SIUFCONWYBJSOP-WCCKRBBISA-N |
| SMILES | CC(C)(CC(C(=O)O)N)C(F)F.Cl |
| Reference | [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107. [2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. |
