For research use only. Not for therapeutic Use.
NV-5138 (Cat.No:I017980) is a novel compound under investigation as a potential treatment for neuropsychiatric disorders, particularly depression. It acts as a selective brain-penetrant glycine site functional partial agonist of the N-methyl-D-aspartate (NMDA) receptor. Preclinical studies suggest that NV-5138 may enhance synaptic plasticity and show antidepressant-like effects, offering promise for future therapeutic interventions.
| Catalog Number | I017980 |
| CAS Number | 2095886-80-7 |
| Molecular Formula | C₇H₁₃F₂NO₂ |
| Purity | ≥95% |
| Target | mTOR |
| Reference | [1]. Sengupta S, et al. Discovery of NV-5138, the first selective Brain mTORC1 activator. Sci Rep. 2019 Mar 11;9(1):4107.<br>[2]. Kato T, et al. Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation. J Clin Invest. 2019 Apr 16;129(6):2542-2554. |
