For research use only. Not for therapeutic Use.
NVOC cage-TMP-Halo is a cell-permeable and photoactivatable protein dimerization inducer. NVOC cage-TMP-Halo can rapidly and reversibly control protein localization in living cells. NVOC cage-TMP-Halo can be used for dynamic cellular processes research[1].
NVOC cage-TMP-Halo (20μM, 60 min) exhibited dramatic recruitment of mCherry-eDHFR to centromeres with a t1/2 of ~ 15 s of expressing CENPB-GFP-Haloenzyme and mCherry-eDHFR HeLa cell line[1].
NVOC cage-TMP-Halo (20μM, 15, 30, and 60 min) has the power for spatially precise manipulation of protein localization in HeLa cell line[1].
| Catalog Number | I040788 |
| CAS Number | 2137894-98-3 |
| Synonyms | (4,5-dimethoxy-2-nitrophenyl)methyl N-[4-amino-5-[[4-[3-[[4-[2-[2-(6-chlorohexoxy)ethoxy]ethylamino]-4-oxobutanoyl]amino]propoxy]-3,5-dimethoxyphenyl]methyl]pyrimidin-2-yl]carbamate |
| Molecular Formula | C40H56ClN7O13 |
| Purity | ≥95% |
| InChI | InChI=1S/C40H56ClN7O13/c1-54-31-23-29(30(48(52)53)24-32(31)55-2)26-61-40(51)47-39-45-25-28(38(42)46-39)20-27-21-33(56-3)37(34(22-27)57-4)60-16-9-13-43-35(49)10-11-36(50)44-14-17-59-19-18-58-15-8-6-5-7-12-41/h21-25H,5-20,26H2,1-4H3,(H,43,49)(H,44,50)(H3,42,45,46,47,51) |
| InChIKey | DUNVDVWPSITHRB-UHFFFAOYSA-N |
| SMILES | COC1=CC(=CC(=C1OCCCNC(=O)CCC(=O)NCCOCCOCCCCCCCl)OC)CC2=CN=C(N=C2N)NC(=O)OCC3=CC(=C(C=C3[N+](=O)[O-])OC)OC |
| Reference | [1]. Ballister ER, et al. Localized light-induced protein dimerization in living cells using a photocaged dimerizer. Nat Commun. 2014 Nov 17;5:5475. |
