For research use only. Not for therapeutic Use.
NVP-QAV-572 is a PI3K inhibitor extracted from patent US7998990B2, Compound Example 8, has an IC50 of 10 nM.
NVP-QAV-572 (Example 8) is useful in the treatment of conditions which are mediated by the activation of the Pi3 kinase enzymes, particularly inflammatory or allergic conditions[1].
| Catalog Number | I005677 |
| CAS Number | 957209-68-6 |
| Synonyms | 1-[2-[2-(2-fluoroethyl)tetrazol-5-yl]ethyl]-3-[5-(3-fluoro-4-methylsulfonylphenyl)-4-methyl-1,3-thiazol-2-yl]urea |
| Molecular Formula | C17H19F2N7O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H19F2N7O3S2/c1-10-15(11-3-4-13(12(19)9-11)31(2,28)29)30-17(21-10)22-16(27)20-7-5-14-23-25-26(24-14)8-6-18/h3-4,9H,5-8H2,1-2H3,(H2,20,21,22,27) |
| InChIKey | UGEZRRNNFHAJTM-UHFFFAOYSA-N |
| SMILES | CC1=C(SC(=N1)NC(=O)NCCC2=NN(N=N2)CCF)C3=CC(=C(C=C3)S(=O)(=O)C)F |
| Reference | [1]. Emma Budd, et al. 5-phenyl-thiazol-2-yl-urea derivatives and use as PI3 kinase inhibitors. US 7998990 B2. |
