NVR 3-778

For research use only. Not for therapeutic Use.

  • CAT Number: I002039
  • CAS Number: 1445790-55-5
  • PubChem Substance ID: 89663273
  • Molecular Formula: C18H16F4N2O4S
  • Molecular Weight: 432.40
  • Purity: ≥95%
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NVR 3-778(Cat No.:I002039)is an investigational antiviral agent targeting hepatitis B virus (HBV) replication. As a capsid assembly modulator (CAM), it disrupts the formation of HBV nucleocapsids, inhibiting viral replication. Clinical studies have demonstrated that NVR 3-778 effectively reduces HBV DNA and RNA levels in patients, with enhanced efficacy observed when combined with pegylated interferon.Despite its promising antiviral activity, development of NVR 3-778 was discontinued due to limited efficacy at feasible doses and potential adverse effects.Nonetheless, its mechanism has informed the development of new CAMs for HBV treatment.


CAS Number 1445790-55-5
Molecular Formula C18H16F4N2O4S
Purity ≥95%
Target HBV
IUPAC Name 4-fluoro-3-(4-hydroxypiperidin-1-yl)sulfonyl-N-(3,4,5-trifluorophenyl)benzamide
InChI InChI=1S/C18H16F4N2O4S/c19-13-2-1-10(18(26)23-11-8-14(20)17(22)15(21)9-11)7-16(13)29(27,28)24-5-3-12(25)4-6-24/h1-2,7-9,12,25H,3-6H2,(H,23,26)
InChIKey KKMFSVNFPUPGCA-UHFFFAOYSA-N
SMILES C1CN(CCC1O)S(=O)(=O)C2=C(C=CC(=C2)C(=O)NC3=CC(=C(C(=C3)F)F)F)F

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