For research use only. Not for therapeutic Use.
NVS-STG2 is a molecular glue that targets STING and activates STING-mediated immune signaling. NVS-STG2 induces higher-order oligomerization of human STING by binding to pockets between adjacent STING dimer transmembrane domains, effectively acting as a molecular glue. NVS-STGI enhances the activity of cGAMP by inducing the formation of more abundant and larger oligomers. NVS-STG2 produces antitumor activity in animal models[1][2].
| Catalog Number | I040266 |
| CAS Number | 3030588-01-0 |
| Synonyms | 4-[[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methylamino]-3-methoxybenzoic acid |
| Molecular Formula | C25H33NO5 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H33NO5/c1-23(2,3)25(30-15-24(4,5)16-31-25)19-10-7-17(8-11-19)14-26-20-12-9-18(22(27)28)13-21(20)29-6/h7-13,26H,14-16H2,1-6H3,(H,27,28) |
| InChIKey | CZSPKEVHLRWAFC-UHFFFAOYSA-N |
| SMILES | CC1(COC(OC1)(C2=CC=C(C=C2)CNC3=C(C=C(C=C3)C(=O)O)OC)C(C)(C)C)C |
| Reference | [1]. Li J et al. Activation of human STING by a molecular glue-like compound. Nat Chem Biol. 2023 Oct 12. [2]. Sulpizio A, et al. A new road to STING activation. Nat Chem Biol. 2023 Oct 13. |
