For research use only. Not for therapeutic Use.
NVX-207 (Cat.No:I007704) is a synthetic compound currently under investigation as a potential antiviral agent. It belongs to the class of nucleoside analogues and has shown activity against various viral infections. NVX-207 works by inhibiting viral replication and has demonstrated efficacy in preclinical studies. Further research is being conducted to evaluate its therapeutic potential.
| Catalog Number | I007704 |
| CAS Number | 745020-66-0 |
| Synonyms | NVX-207; NVX207; NVX 207;2-amino-3-hydroxy-2-(hydroxymethyl)propyl (1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-acetoxy-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylate |
| Molecular Formula | C36H59NO6 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| InChI | InChI=1S/C36H59NO6/c1-22(2)24-11-16-36(30(41)42-21-35(37,19-38)20-39)18-17-33(7)25(29(24)36)9-10-27-32(6)14-13-28(43-23(3)40)31(4,5)26(32)12-15-34(27,33)8/h24-29,38-39H,1,9-21,37H2,2-8H3/t24-,25+,26-,27+,28-,29+,32-,33+,34+,36-/m0/s1 |
| InChIKey | KQZVSTAVTJCKDG-DRSBITMPSA-N |
| SMILES | O=C([C@]1(CC[C@H]2C(C)=C)[C@@]2([H])[C@@]3([H])CC[C@]4([H])[C@@]5(C)CC[C@H](OC(C)=O)C(C)(C)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC1)OCC(CO)(N)CO |
| Reference | </br>1:In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses. Liebscher G, Vanchangiri K, Mueller T, Feige K, Cavalleri JM, Paschke R.Chem Biol Interact. 2016 Feb 25;246:20-9. doi: 10.1016/j.cbi.2016.01.002. Epub 2016 Jan 7. PMID: 26772157 </br>2:Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma–an in vitro study of cytotoxicity and radiosensitization. Bache M, Bernhardt S, Passin S, Wichmann H, Hein A, Zschornak M, Kappler M, Taubert H, Paschke R, Vordermark D.Int J Mol Sci. 2014 Oct 30;15(11):19777-90. doi: 10.3390/ijms151119777. PMID: 25361208 Free PMC Article</br>3:Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Willmann M, Wacheck V, Buckley J, Nagy K, Thalhammer J, Paschke R, Triche T, Jansen B, Selzer E.Eur J Clin Invest. 2009 May;39(5):384-94. doi: 10.1111/j.1365-2362.2009.02105.x. PMID: 19309323 |
