For research use only. Not for therapeutic Use.
Nystatin（Cat No.:I001524）is a polyene antifungal medication widely used to treat fungal infections caused by Candida species. It works by binding to ergosterol, a critical component of fungal cell membranes, disrupting membrane integrity and causing cell death. Nystatin is primarily used for localized infections, including oral thrush, diaper rash, and vaginal yeast infections. Available in topical, oral, and suspension forms, it is effective for treating superficial fungal infections without significant systemic absorption. Nystatin is a safe and well-tolerated antifungal, making it a preferred choice for mild to moderate fungal infections.
| Catalog Number | I001524 |
| CAS Number | 1400-61-9 |
| Synonyms | (4E,6E,8E,10E,14E,16E,18S,19R,20R,21S,35S)-3-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-19,25,27,29,32,33,35,37-octahydroxy-18,20,21-trimethyl-23-oxo-22,39-dioxabicyclo[33.3.1]nonatriaconta-4,6,8,10,14,16-hexaene-38-carboxylic acid |
| Molecular Formula | C47H75NO17 |
| Purity | ≥95% |
| Target | Antibiotic |
| Solubility | DMSO: ≤ 24 mg/mL |
| Storage | Store at -20C |
| IUPAC Name | (1S,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E)-33-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid |
| InChI | InChI=1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31?,32?,33?,34?,35?,36?,37?,38?,40?,41-,42+,43+,44-,46+,47+/m0/s1 |
| InChIKey | VQOXZBDYSJBXMA-RKEBNKJGSA-N |
| SMILES | C[C@H]1/C=C/C=C/CC/C=C/C=C/C=C/C=C/C(CC2C(C(C[C@](O2)(CC(C(CCC(CC(CC(CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
| Reference | </br>1:Synergistic anticandidal activity of menthol in combination with itraconazole and nystatin against clinical Candida glabrata and Candida krusei isolates. Sharifzadeh A, Khosravi AR, Shokri H, Tari PS.Microb Pathog. 2017 Apr 19;107:390-396. doi: 10.1016/j.micpath.2017.04.021. [Epub ahead of print] PMID: 28431915 </br>2:Severe contact dermatitis due to ethylenediamine dihydrochloride in nystatin cream. Iammatteo M, Akenroye A, Jariwala S, Lee B, Schairer D, Rosenstreich D.J Allergy Clin Immunol Pract. 2017 Apr 7. pii: S2213-2198(17)30175-7. doi: 10.1016/j.jaip.2017.03.006. [Epub ahead of print] No abstract available. PMID: 28396110 </br>3:Nystatin and disinfectant solutions seem to be effective in treating denture stomatitis. Brignardello-Petersen R.J Am Dent Assoc. 2017 Apr;148(4):e32. doi: 10.1016/j.adaj.2017.02.008. Epub 2017 Feb 24. No abstract available. PMID: 28242007 </br>4:QUESTION 2: Does prophylactic nystatin prevent invasive fungal infections in immunocompetent critically ill children on broad-spectrum antibiotics? Beake M, Fraser J.Arch Dis Child. 2017 Mar;102(3):288-291. doi: 10.1136/archdischild-2016-311891. No abstract available. PMID: 28213455 </br>5:Identification of multi-targeted anti-migraine potential of nystatin and development of its brain targeted chitosan nanoformulation. Girotra P, Thakur A, Kumar A, Singh SK.Int J Biol Macromol. 2017 Mar;96:687-696. doi: 10.1016/j.ijbiomac.2016.12.065. Epub 2016 Dec 29. PMID: 28041915 </br>6:Preparation, Physicochemical Characterization and Anti-fungal Evaluation of Nystatin-Loaded PLGA-Glucosamine Nanoparticles. Mohammadi G, Shakeri A, Fattahi A, Mohammadi P, Mikaeili A, Aliabadi A, Adibkia K.Pharm Res. 2017 Feb;34(2):301-309. doi: 10.1007/s11095-016-2062-6. Epub 2016 Dec 7. PMID: 27928646 </br>7:The Effect of Nystatin Solution on Otoacoustic Emissions in Rats. Vural A, Şahin Mİ, Aydın M, Gündoğdu R, Arlı T, Okuducu H, Dizdar D, Külahlı İ.J Int Adv Otol. 2016 Nov 7. doi: 10.5152/iao.2016.1667. [Epub ahead of print] PMID: 27819649 </br>8:Synthesis, antifungal activity of caffeic acid derivative esters, and their synergism with fluconazole and nystatin against Candida spp. Sardi JC, Gullo FP, Freires IA, Pitangui NS, Segalla MP, Fusco-Almeida AM, Rosalen PL, Regasini LO, Mendes-Giannini MJ.Diagn Microbiol Infect Dis. 2016 Dec;86(4):387-391. doi: 10.1016/j.diagmicrobio.2016.08.002. Epub 2016 Aug 8. PMID: 27638348 </br>9:Anti-Rhodotorula activity of mycophenolic acid enhanced in the presence of polyene antibiotic nystatin. Kinoshita H, Wongsuntornpoj S, Ihara F, Nihira T.Lett Appl Microbiol. 2017 Feb;64(2):144-149. doi: 10.1111/lam.12692. Epub 2016 Dec 6. PMID: 27801509 </br>10:Osmotic Effects Induced by Pore-Forming Agent Nystatin: From Lipid Vesicles to the Cell. Zemljič Jokhadar Š, Božič B, Kristanc L, Gomišček G.PLoS One. 2016 Oct 27;11(10):e0165098. doi: 10.1371/journal.pone.0165098. eCollection 2016. PMID: 27788169 Free PMC Article |
