O-(2-Aminoethyl)-O’-(2-azidoethyl)tetraethylene Glycol

For research use only. Not for therapeutic Use.

  • CAT Number: R054686
  • CAS Number: 516493-93-9
  • Molecular Formula: C12H26N4O5
  • Molecular Weight: 306.363
  • Purity: ≥95%
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Amino-PEG5-azide(CAS: 516493-93-9) is developed as a bifunctional PEG reagent with great solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.


Catalog Number R054686
CAS Number 516493-93-9
Synonyms

17-Azido-3,6,9,12,15-pentaoxaheptadecan-1-amine;Azido-PEG5-Amine; N3-PEG5-CH2CH2NH2。

Molecular Formula C12H26N4O5
Purity ≥95%
Target PROTAC Linkers
Storage Store at -20C
IUPAC Name 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
InChI InChI=1S/C12H26N4O5/c13-1-3-17-5-7-19-9-11-21-12-10-20-8-6-18-4-2-15-16-14/h1-13H2
InChIKey SVPBRIZYFJFLOL-UHFFFAOYSA-N
SMILES C(COCCOCCOCCOCCOCCN=[N+]=[N-])N
Reference

[1]. Yuan, S., Chu, H., Chan, J.F.W., Ye, Z.W., Wen, L., Yan, B., Lai, P.M., Tee, K.M., Huang, J., Chen, D. and Li, C., 2019.<br />
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.<br />
Abstract: Viruses are obligate intracellular microbes that exploit the host metabolic machineries to meet their biosynthetic demands, making these host pathways potential therapeutic targets. Here, by exploring a lipid library, we show that AM580, a retinoid derivative and RAR-&alpha; agonist, is highly potent in interrupting the life cycle of diverse viruses including Middle East respiratory syndrome coronavirus and influenza A virus. Using click chemistry, the overexpressed sterol regulatory element binding protein (SREBP) is shown to interact with AM580, which accounts for its broad-spectrum antiviral activity. Mechanistic studies pinpoint multiple SREBP proteolytic processes and SREBP-regulated lipid biosynthesis pathways, including the downstream viral protein palmitoylation and double-membrane vesicles formation, that are indispensable for virus replication. Collectively, our study identifies a basic lipogenic transactivation event with broad relevance to human viral infections and represents SREBP as a potential target for the development of broad-spectrum antiviral strategies.<br />
Nature communications, 10(1), pp.1-15.

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