For research use only. Not for therapeutic Use.
(±)-<wbr></wbr>2-<wbr></wbr>Methyl arachidonoyl-<wbr></wbr>2/’-<wbr></wbr>fluoroethylamide (2-<wbr></wbr>Methyl-<wbr></wbr>2/’-<wbr></wbr>fluoro AEA) is an analog of anandamide (AEA) in which the alcohol of the ethanolamide group has been removed and replaced with a fluorine atom. This substitution confers considerably increased binding affinity for the CB<sub>1</sub> receptor (K<sub>i</sub> = 5.7 nM in rat brain). It also confers additional selectivity, in that binding to CB<sub>2</sub> is decreased relative to AEA. However, the <em>in vivo</em> activity of 2-<wbr></wbr>fluoro AEA is enhanced much less than the binding affinity, because the analog remains a good substrate for FAAH and is rapidly hydrolyzed by this enzyme. 2-<wbr></wbr>Methyl-<wbr></wbr>2/’-<wbr></wbr>fluoro AEA is further modified by the addition of an α-<wbr></wbr>methyl group at the C-<wbr></wbr>2 position of arachidonic acid. This substitution confers enhanced metabolic stability. 2-<wbr></wbr>Methyl-<wbr></wbr>2/’-<wbr></wbr>fluoro AEA can fully substitute for Δ
| Catalog Number | M043881 |
| CAS Number | 166100-39-6 |
| Synonyms | 2-methyl-2′-fluoro AEA;2-Methyl-2′-fluoro Anandamide;O-689 |
| Molecular Formula | C23H38FNO |
| Purity | ≥95% |
| Target | Apoptosis |
| Storage | -20°C |
| InChIKey | HMMNZALKMVCHHZ-ZKWNWVNESA-N |
