O-Desmethyl Adapalene

• CAT Number: R049375
• CAS Number: 125316-60-1
• Molecular Formula: C27H26O3
• Molecular Weight: 398.50
• Purity: ≥95%
• Synonyms: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic Acid; 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic Acid; AHPN; CD 437; CD 437/AHPN
• Target: RARs
• Solubility: Soluble in DMSO > 10 mM
• Storage: Store at -20C
• IUPAC Name: 6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
• InChI: InChI=1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30)
• InChIKey: LDGIHZJOIQSHPB-UHFFFAOYSA-N
• SMILES: C1C2CC3CC1CC(C2)(C3)C4=C(C=CC(=C4)C5=CC6=C(C=C5)C=C(C=C6)C(=O)O)O

O-Desmethyl Adapalene（Cat No.:R049375）is a metabolite of adapalene, a third-generation topical retinoid used for acne treatment. This compound retains adapalene’s properties, interacting with nuclear retinoic acid receptors to regulate cell turnover, reducing inflammation and keratinization in the skin. By promoting exfoliation and preventing clogged pores, O-Desmethyl Adapalene aids in acne management and is of interest in dermatological research for its potential in skin renewal therapies. Its action on skin cell differentiation and anti-inflammatory pathways supports ongoing studies into retinoid-based treatments for acne and other skin disorders.