O-Desmethyl gefitinib-d8

• CAT Number: S000464
• CAS Number: 847949-49-9
• Molecular Formula: C21H14D8ClFN4O3
• Molecular Weight: 440.93
• Purity: ≥95%
• Target: Protein Tyrosine Kinase/RTK
• IUPAC Name: 4-(3-chloro-4-fluoroanilino)-6-[3-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)propoxy]quinazolin-7-ol
• InChI: InChI=1S/C21H22ClFN4O3/c22-16-10-14(2-3-17(16)23)26-21-15-11-20(19(28)12-18(15)24-13-25-21)30-7-1-4-27-5-8-29-9-6-27/h2-3,10-13,28H,1,4-9H2,(H,24,25,26)/i5D2,6D2,8D2,9D2
• InChIKey: IFMMYZUUCFPEHR-RHDPTBQRSA-N
• SMILES: C1COCCN1CCCOC2=C(C=C3C(=C2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl)O

O-Desmethyl gefitinib-d8（Cat No.:S000464） is a deuterated form of O-desmethyl gefitinib, where eight hydrogen atoms are replaced with deuterium. This modified molecule is essential for investigating pharmacokinetics and metabolic stability. O-Desmethyl gefitinib is an active metabolite of gefitinib, a drug used primarily in the treatment of non-small cell lung cancer. Gefitinib targets and inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase, which is involved in the growth and spread of cancer cells.