For research use only. Not for therapeutic Use.
O-Nornuciferine, an aporphine-type alkaloid from lotus leaf, is a potent hERG channel inhibitor[1].
O-Nornuciferine has an IC50 of 7.91 μM in vitro hERG blockages measured in HEK293 cells[1].
O-Nornuciferine (100 μM) has 47% hERG channel inhibition in Xenopus oocytes by lotus alkaloids[1].
| Catalog Number | R053272 |
| CAS Number | 3153-55-7 |
| Synonyms | (6aR)-1-methoxy-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-2-ol |
| Molecular Formula | C18H19NO2 |
| Purity | ≥95% |
| InChI | InChI=1S/C18H19NO2/c1-19-8-7-12-10-15(20)18(21-2)17-13-6-4-3-5-11(13)9-14(19)16(12)17/h3-6,10,14,20H,7-9H2,1-2H3/t14-/m1/s1 |
| InChIKey | AKXOIHNFHOEPHN-CQSZACIVSA-N |
| SMILES | CN1CCC2=CC(=C(C3=C2C1CC4=CC=CC=C43)OC)O |
| Reference | [1]. Ulrike Grienke, et al. Human Ether-à-go-go Related Gene (hERG) Channel Blocking Aporphine Alkaloids From Lotus Leaves and Their Quantitative Analysis in Dietary Weight Loss Supplements. J Agric Food Chem. 2015 Jun 17;63(23):5634-9. |
