O4I2

• CAT Number: I002167
• CAS Number: 165682-93-9
• Molecular Formula: C12H11ClN2O2S
• Molecular Weight: 282.7
• Purity: ≥95%
• Synonyms: 2-[(4-chlorophenyl)amino]- 4-thiazolecarboxylic acid, ethyl ester
• Target: Oct3/4
• Solubility: DMSO: ≥ 42 mg/mL
• Storage: -20°C
• InChI: InChI=1S/C12H11ClN2O2S/c1-2-17-11(16)10-7-18-12(15-10)14-9-5-3-8(13)4-6-9/h3-7H,2H2,1H3,(H,14,15)
• InChIKey: ULUBAPWNHROTEU-UHFFFAOYSA-N
• SMILES: ClC1=CC=C(NC2=NC(C(OCC)=O)=CS2)C=C1

O4I2 (CAT: I002167) is a potent inducer of Oct3/4 expression in various human cell lines, including human fibroblasts. Oct3/4, also known as POU5F1, is a critical transcription factor involved in maintaining pluripotency and self-renewal in embryonic stem cells. O4I2’s ability to induce Oct3/4 expression suggests its potential utility in cellular reprogramming or regenerative medicine applications, where the activation of pluripotency-associated genes is desirable. The compound’s specific mechanism of action and effects on cellular differentiation warrant further investigation for its potential role in stem cell research and related therapeutic strategies.

Reference

[1]. Cheng X, et al. Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4. J Med Chem. 2015 Aug 13;58(15):5742-5750.