O6-Benzylguanine

• CAT Number: R000036
• CAS Number: 19916-73-5
• Molecular Formula: C12H11N5O
• Molecular Weight: 241.25
• Purity: ≥95%
• Synonyms: 6-(Phenylmethoxy)-9H-purin-2-amine; 2-Amino-6-(benzyloxy)purine; NSC 637037
• Target: Apoptosis
• Storage: -20°C
• IUPAC Name: 6-phenylmethoxy-7H-purin-2-amine
• InChI: InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)
• InChIKey: KRWMERLEINMZFT-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COC2=NC(=NC3=C2NC=N3)N

O6-Benzylguanine（Cat No.:R000036）is a synthetic compound that functions as an inhibitor of the DNA repair enzyme O6-alkylguanine-DNA alkyltransferase (AGT). AGT plays a key role in repairing DNA damage caused by alkylating agents, which are commonly used in cancer chemotherapy. By inhibiting AGT, O6-benzylguanine enhances the effectiveness of alkylating chemotherapeutic drugs, allowing for greater DNA damage in cancer cells and improving their cytotoxicity. It has been studied as a potential chemotherapeutic adjuvant to overcome drug resistance and sensitize tumors to treatment. However, its clinical use is limited by side effects and challenges in delivery.