OA 6129C

• CAT Number: I033747
• CAS Number: 82475-09-0
• Molecular Formula: C20H31N3O11S2
• Molecular Weight: 553.598
• Purity: 98%
• Synonyms: OA 6129C; OA-6129C; OA6129C; Antibiotic OA 6129C; Antibiotic OA-6129C; Antibiotic OA6129C
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-((2-(3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanamido)ethyl)thio)-7-oxo-6-(1-(sulfooxy)ethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• InChI: InChI=1S/C20H31N3O11S2/c1-10(34-36(31,32)33)14-11-8-12(15(19(29)30)23(11)18(14)28)35-7-6-21-13(25)4-5-22-17(27)16(26)20(2,3)9-24/h10-11,14,16,24,26H,4-9H2,1-3H3,(H,21,25)(H,22,27)(H,29,30)(H,31,32,33)
• InChIKey: GRWWKENHBQJAML-UHFFFAOYSA-N
• SMILES: CC(C1C2CC(SCCNC(CCNC(C(C(C)(CO)C)O)=O)=O)=C(C(O)=O)N2C1=O)OS(=O)(O)=O

OA 6129C is a new carbapenem antibiotic.

Reference

1: Kojima I, Fukagawa Y, Okabe M, Ishikura T, Shibamoto N. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems. J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899. PMID: 3417564.
2: Kubo K, Ishikura T, Fukagawa Y. Microbial phosphorylation of the OA-6129 group of carbapenem compounds. J Antibiot (Tokyo). 1985 Mar;38(3):333-9. doi: 10.7164/antibiotics.38.333. PMID: 3839225.
3: Kubo K, Ishikura T, Fukagawa Y. Studies on the biosynthesis of carbapenem antibiotics. II. Isolation and functions of a specific acylase involved in the depantothenylation of the OA-6129 compounds. J Antibiot (Tokyo). 1984 Nov;37(11):1394-402. doi: 10.7164/antibiotics.37.1394. PMID: 6511667.
4: Fukagawa Y, Okabe M, Azuma S, Kojima I, Ishikura T, Kubo K. Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880. J Antibiot (Tokyo). 1984 Nov;37(11):1388-93. doi: 10.7164/antibiotics.37.1388. PMID: 6511666.
5: Yoshioka T, Kojima I, Isshiki K, Watanabe A, Shimauchi Y, Okabe M, Fukagawa Y, Ishikura T. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129. J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473. PMID: 6654757.
6: Okabe M, Azuma S, Kojima I, Kouno K, Okamoto R, Fukagawa Y, Ishikura T. Studies on the OA-6129 group of antibiotics, new carbapenem compounds. I. Taxonomy, isolation and physical properties. J Antibiot (Tokyo). 1982 Oct;35(10):1255-63. doi: 10.7164/antibiotics.35.1255. PMID: 7174513.