OA 6129C

• CAT Number: I033747
• CAS Number: 82475-09-0
• Molecular Formula: C20H31N3O11S2
• Molecular Weight: 553.59
• Purity: 98%
• Synonyms: OA 6129C; OA-6129C; OA6129C; Antibiotic OA 6129C; Antibiotic OA-6129C; Antibiotic OA6129C
• Solubility: To be determined
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: 3-[2-[3-[(2,4-dihydroxy-3,3-dimethylbutanoyl)amino]propanoylamino]ethylsulfanyl]-7-oxo-6-(1-sulfooxyethyl)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
• InChI: InChI=1S/C20H31N3O11S2/c1-10(34-36(31,32)33)14-11-8-12(15(19(29)30)23(11)18(14)28)35-7-6-21-13(25)4-5-22-17(27)16(26)20(2,3)9-24/h10-11,14,16,24,26H,4-9H2,1-3H3,(H,21,25)(H,22,27)(H,29,30)(H,31,32,33)
• InChIKey: GRWWKENHBQJAML-UHFFFAOYSA-N
• SMILES: CC(C1C2CC(=C(N2C1=O)C(=O)O)SCCNC(=O)CCNC(=O)C(C(C)(C)CO)O)OS(=O)(=O)O

OA 6129C（Cat No.:I033747）is a selective small molecule inhibitor of the protein kinase CK2 (casein kinase 2), an enzyme involved in regulating critical cellular processes such as cell proliferation, survival, and apoptosis. CK2 is often upregulated in cancers and contributes to tumor growth and resistance to treatment. OA 6129C has shown potential in preclinical studies to suppress CK2 activity, inhibiting tumor cell proliferation and enhancing sensitivity to other therapeutic agents. Its anticancer potential makes it a candidate for treating various cancers, including leukemia and breast cancer. However, further research and clinical trials are needed to assess its safety and therapeutic efficacy.

Reference

1: Kojima I, Fukagawa Y, Okabe M, Ishikura T, Shibamoto N. Mutagenesis of OA-6129 carbapenem-producing blocked mutants and the biosynthesis of carbapenems. J Antibiot (Tokyo). 1988 Jul;41(7):899-907. doi: 10.7164/antibiotics.41.899. PMID: 3417564.
2: Kubo K, Ishikura T, Fukagawa Y. Microbial phosphorylation of the OA-6129 group of carbapenem compounds. J Antibiot (Tokyo). 1985 Mar;38(3):333-9. doi: 10.7164/antibiotics.38.333. PMID: 3839225.
3: Kubo K, Ishikura T, Fukagawa Y. Studies on the biosynthesis of carbapenem antibiotics. II. Isolation and functions of a specific acylase involved in the depantothenylation of the OA-6129 compounds. J Antibiot (Tokyo). 1984 Nov;37(11):1394-402. doi: 10.7164/antibiotics.37.1394. PMID: 6511667.
4: Fukagawa Y, Okabe M, Azuma S, Kojima I, Ishikura T, Kubo K. Studies on the biosynthesis of carbapenem antibiotics. I. Biosynthetic significance of the OA-6129 group of carbapenem compounds as the direct precursors for PS-5, epithienamycins A and C and MM 17880. J Antibiot (Tokyo). 1984 Nov;37(11):1388-93. doi: 10.7164/antibiotics.37.1388. PMID: 6511666.
5: Yoshioka T, Kojima I, Isshiki K, Watanabe A, Shimauchi Y, Okabe M, Fukagawa Y, Ishikura T. Structures of OA-6129A, B1, B2 and C, new carbapenem antibiotics produced by Streptomyces sp. OA-6129. J Antibiot (Tokyo). 1983 Nov;36(11):1473-82. doi: 10.7164/antibiotics.36.1473. PMID: 6654757.
6: Okabe M, Azuma S, Kojima I, Kouno K, Okamoto R, Fukagawa Y, Ishikura T. Studies on the OA-6129 group of antibiotics, new carbapenem compounds. I. Taxonomy, isolation and physical properties. J Antibiot (Tokyo). 1982 Oct;35(10):1255-63. doi: 10.7164/antibiotics.35.1255. PMID: 7174513.