OAT-1441

• CAT Number: I033760
• CAS Number: 2088453-79-4
• Molecular Formula: C23H27ClN6O
• Molecular Weight: 438.95
• Purity: ≥95%
• IUPAC Name: 3-[4-[(3S)-3-[(4-chlorophenyl)methyl]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]piperidin-1-yl]-1H-1,2,4-triazol-5-amine
• InChI: InChI=1S/C23H27ClN6O/c24-18-7-5-16(6-8-18)13-20-15-31-21-4-2-1-3-17(21)14-30(20)19-9-11-29(12-10-19)23-26-22(25)27-28-23/h1-8,19-20H,9-15H2,(H3,25,26,27,28)/t20-/m0/s1
• SMILES: C1CN(CCC1N2CC3=CC=CC=C3OC[C@@H]2CC4=CC=C(C=C4)Cl)C5=NNC(=N5)N

OAT-1441 is the first highly potent, selective and orally bioavailable inhibitor of human acidic mammalian chitinase (hAMCase) with an IC50 value of 7 nM.
KEYWORDS: OAT-1441 | Supplier | hAMCase inhibitor | OAT1441 | OAT 1441 | CAS [2088453-79-4] | [2088453-80-7] | Chitin | Chitinase | Inhibitor | Enzymes | Asthma | Allergic inflammation

Reference

G Andryianau et al. Benzoxazepine-Derived Selective, Orally Bioavailable Inhibitor of Human Acidic Mammalian Chitinase. ACS Med Chem Lett. 2020 Apr 24;11(6):1228-1235.