For research use only. Not for therapeutic Use.
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin[1].
OB-1 (3 h) reduces mechanotransduction currents in in N2a cells with an IC50 of 10 nM[1].
OB-1 (250-500 pmol per paw; s.c.; once) reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in mice[1].
OB-1 (250 pmol per paw; s.c.; once) alleviates painful diabetic neuropathy in mice[1].
| Catalog Number | I033764 |
| CAS Number | 300803-69-4 |
| Synonyms | ethyl 5-(3-methyl-5-nitroimidazol-4-yl)oxy-2-phenyl-1-benzofuran-3-carboxylate |
| Molecular Formula | C21H17N3O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C21H17N3O6/c1-3-28-21(25)17-15-11-14(29-20-19(24(26)27)22-12-23(20)2)9-10-16(15)30-18(17)13-7-5-4-6-8-13/h4-12H,3H2,1-2H3 |
| InChIKey | UJHGRDVYTTVJFD-UHFFFAOYSA-N |
| SMILES | CCOC(=O)C1=C(OC2=C1C=C(C=C2)OC3=C(N=CN3C)[N+](=O)[O-])C4=CC=CC=C4 |
| Reference | [1]. Wetzel C, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nat Neurosci. 2017 Feb;20(2):209-218. |
