OBA-09

• CAT Number: I005134
• CAS Number: 856095-68-6
• Molecular Formula: C10H8O5
• Molecular Weight: 208.17
• Purity: ≥95%
• Synonyms: Pyruvic Acid;Salicylic Acid ester
• Target: NF-κB
• Solubility: 10 mM in DMSO
• Storage: 4°C
• IUPAC Name: 2-(2-oxopropanoyloxy)benzoic acid
• InChI: 1S/C10H8O5/c1-6(11)10(14)15-8-5-3-2-4-7(8)9(12)13/h2-5H,1H3,(H,12,13)
• InChIKey: ULWCDKMLERRCJA-UHFFFAOYSA-N
• SMILES: CC(=O)C(=O)OC1=CC=CC=C1C(=O)O

OBA-09 (Cat No.: I005134) is a neuroprotective agent that inhibits necroptosis, a regulated form of cell death implicated in neurodegenerative diseases and ischemic injury. It targets receptor-interacting protein kinases (RIPK1 and RIPK3) to prevent excessive neuronal loss and inflammation. OBA-09 has been studied for its potential therapeutic applications in stroke, traumatic brain injury, and neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. By modulating necroptotic pathways, OBA-09 serves as a valuable tool in neurobiology research and drug discovery for neuroprotection.

Reference

[1]. Kim SW, et al. Robust protective effects of a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester) in the postischemic brain. Mol Pharmacol. 2011 Feb;79(2):220-8.