For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>OBA-09 is a novel multimodal neuroprotectant oxopropanoyloxy benzoic acid (a salicylic acid/pyruvate ester); shows robust protective effects in the postischemic brain.<br>IC50 value:<br>Target:<br>OBA-09 exhibited antioxidative effects in the postischemic brain, which was evidenced by remarkable reduction of lipid peroxidation and 4-hydroxy-2-nonenal staining in OBA-09-administered animals. Reactive oxygen species generation was markedly suppressed in primary cortical cultures under oxygen-glucose deprivation. More interestingly, OBA-09 was capable of scavenging hydroxyl radical in cell-free assays. High-performance liquid chromatography results demonstrated that OBA-09 was hydrolyzed to salicylic acid and pyruvate with t1/2 = 43 min in serum and 4.2 h in brain parenchyma, indicating that antioxidative function of OBA-09 is executed by itself and also by salicylic acid after the hydrolysis. In addition to antioxidative function, OBA-09 exerts anti-excitotoxic and anti-Zn2+-toxic functions, which might be attributed to attenuation of ATP and nicotinamide adenine dinucleotide depletion and to the suppression of nuclear factor-κB activity induction. Together these results indicate that OBA-09 has a potent therapeutic potential as a multimodal neuroprotectant in the postischemic brain and these effects were conferred by OBA-09 itself and subsequently its hydrolyzed products.</p>
| Catalog Number | I005134 |
| CAS Number | 856095-68-6 |
| Synonyms | Pyruvic Acid;Salicylic Acid ester |
| Molecular Formula | C10H8O5 |
| Purity | ≥95% |
| Target | NF-κB |
| Solubility | 10 mM in DMSO |
| Storage | 4°C |
| InChIKey | ULWCDKMLERRCJA-UHFFFAOYSA-N |
| Reference | <p style=/line-height:25px/> |
