For research use only. Not for therapeutic Use.
Obicetrapib (also known as AMG-899, TA-8995, and DEX-001) is a cholesteryl ester transfer protein (CETP) inhibitor. CETP inhibitors substantially increase the concentration of high-density lipoprotein cholesterol (HDL-C), which may have a possible beneficial effect for cardiovascular disease risk reduction.
| Catalog Number | I008393 |
| CAS Number | 866399-87-3 (free base) |
| Synonyms | Obicetrapib; AMG-899, TA-8995, DEZ-001; AMG 899, TA 8995, DEZ 001; AMG899, TA8995, DEZ001; 866399-87-3 (free base); 866399-89-5 (calcium);4-((2-((3,5-bis(trifluoromethyl)benzyl)((2R,4S)-1-(ethoxycarbonyl)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydr |
| Molecular Formula | C32H31F9N4O5 |
| Purity | ≥95% |
| Target | Cholesteryl Ester Transfer Protein Inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term, or -20 °C for long term |
| SMILES | O=C(O)CCCOC1=CN=C(N(CC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)[C@H]3C[C@@H](CC)N(C(OCC)=O)C4=C3C=C(C(F)(F)F)C=C4)N=C1 |
| Reference | </br>1:Filippatos TD, Klouras E, Barkas F, Elisaf M. Cholesteryl ester transfer protein inhibitors: challenges and perspectives. Expert Rev Cardiovasc Ther. 2016 Aug;14(8):953-62. doi: 10.1080/14779072.2016.1189327. Epub 2016 May 28. PubMed PMID: 27171534.</br>2:Amgen bulks out cardio package. Nat Biotechnol. 2015 Nov;33(11):1118. doi: 10.1038/nbt1115-1118a. PubMed PMID: 26544124.</br>3:Mearns BM. Dyslipidaemia: Promising results for TA-8995 in TULIP. Nat Rev Cardiol. 2015 Aug;12(8):443. doi: 10.1038/nrcardio.2015.97. Epub 2015 Jun 23. PubMed PMID: 26099844. |
