Obicetrapib free base

• CAT Number: I008393
• CAS Number: 866399-87-3 (free base)
• Molecular Formula: C32H31F9N4O5
• Molecular Weight: 722.61
• Purity: ≥95%
• Synonyms: Obicetrapib; AMG-899, TA-8995, DEZ-001; AMG 899, TA 8995, DEZ 001; AMG899, TA8995, DEZ001; 866399-87-3 (free base); 866399-89-5 (calcium);4-((2-((3,5-bis(trifluoromethyl)benzyl)((2R,4S)-1-(ethoxycarbonyl)-2-ethyl-6-(trifluoromethyl)-1,2,3,4-tetrahydr
• Target: Cholesteryl Ester Transfer Protein Inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4 °C for short term, or -20 °C for long term
• IUPAC Name: 4-[2-[[3,5-bis(trifluoromethyl)phenyl]methyl-[(2R,4S)-1-ethoxycarbonyl-2-ethyl-6-(trifluoromethyl)-3,4-dihydro-2H-quinolin-4-yl]amino]pyrimidin-5-yl]oxybutanoic acid
• InChI: InChI=1S/C32H31F9N4O5/c1-3-22-14-26(24-13-19(30(33,34)35)7-8-25(24)45(22)29(48)49-4-2)44(28-42-15-23(16-43-28)50-9-5-6-27(46)47)17-18-10-20(31(36,37)38)12-21(11-18)32(39,40)41/h7-8,10-13,15-16,22,26H,3-6,9,14,17H2,1-2H3,(H,46,47)/t22-,26+/m1/s1
• InChIKey: NRWORBQAOQVYBJ-GJZUVCINSA-N
• SMILES: CC[C@@H]1C[C@@H](C2=C(N1C(=O)OCC)C=CC(=C2)C(F)(F)F)N(CC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)C4=NC=C(C=N4)OCCCC(=O)O

Obicetrapib free base（Cat No.:I008393）is an experimental drug being developed for the treatment of cardiovascular diseases, particularly atherosclerosis and hyperlipidemia. It is a potent inhibitor of cholesteryl ester transfer protein (CETP), an enzyme involved in regulating lipid metabolism and the transfer of cholesterol between lipoproteins. By inhibiting CETP, obicetrapib increases high-density lipoprotein (HDL) cholesterol levels and decreases low-density lipoprotein (LDL) cholesterol, which may help reduce cardiovascular risk. Currently in clinical trials, obicetrapib’s safety, efficacy, and long-term effects are being evaluated, with promising results for lipid management and heart disease prevention.