Octaethylene glycol monomethyl ether

• CAT Number: I015614
• CAS Number: 25990-96-9
• Molecular Formula: C₁₇H₃₆O₉
• Molecular Weight: 384.46
• Purity: ≥95%
• Target: PROTAC Linkers
• Storage: 2-8°C
• IUPAC Name: 2-[2-[2-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
• InChI: InChI=1S/C17H36O9/c1-19-4-5-21-8-9-23-12-13-25-16-17-26-15-14-24-11-10-22-7-6-20-3-2-18/h18H,2-17H2,1H3
• InChIKey: SZGNWRSFHADOMY-UHFFFAOYSA-N
• SMILES: COCCOCCOCCOCCOCCOCCOCCOCCO

Octaethylene glycol monomethyl ether is a polyethylene glycol (PEG)-based linker that is commonly used in the synthesis of proteolysis-targeting chimeras (PROTACs). PROTACs are bifunctional molecules that can selectively target and degrade specific proteins within cells. Octaethylene glycol monomethyl ether acts as a flexible linker, connecting the protein-targeting ligand with the E3 ubiquitin ligase recruiting ligand. The PEG-based nature of the linker provides water solubility and stability to the PROTAC molecule, allowing for efficient cellular penetration and target engagement. This linker has been widely utilized in the development of PROTAC-based therapeutics for targeted protein degradation strategies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562