For research use only. Not for therapeutic Use.
ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5′-tccatgacgttcctgatgct-3’[1][2].
ODN 1668 induces TNF-α secretion and promotes polyclonal B cell activation[1].
ODN 1668 (10 nmol) stimulates responses to protein antigen[1].
ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats[2].
| Catalog Number | I043318 |
| CAS Number | 1186063-66-0 |
| Purity | ≥95% |
| Reference | [1]. Lipford GB, et al. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur J Immunol. 1997 Sep;27(9):2340-4. [2]. Damm J, et al. Intraperitoneal and subcutaneous injections of the TLR9 agonist ODN 1668 in rats: brain inflammatory responses are related to peripheral IL-6 rather than interferons. J Neuroimmunol. 2014 Dec 15;277(1-2):105-17. |
