ODN TTAGGG

• CAT Number: I043311
• CAS Number: 1801724-76-4
• Molecular Weight: 7944.30
• Purity: ≥95%

ODN TTAGGG（Cat No.:I043311）is a synthetic oligodeoxynucleotide (ODN) that mimics the telomeric DNA sequence, specifically targeting the TTAGGG repeat found at the ends of chromosomes. It acts as a ligand for toll-like receptor 9 (TLR9), which is involved in initiating immune responses. By binding to TLR9, ODN TTAGGG activates innate immune cells such as dendritic cells and macrophages, leading to the production of pro-inflammatory cytokines. This compound has been studied for its potential applications in immunotherapy, cancer treatment, and vaccine development, where it can enhance immune responses against tumors or infections.

Reference

[1]. John J Kaminski, et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J Immunol. 2013 Oct 1;191(7):3876-83.
[Content Brief]

[2]. Folkert Steinhagen, et al. Suppressive oligodeoxynucleotides containing TTAGGG motifs inhibit cGAS activation in human monocytes. Eur J Immunol. 2018 Apr;48(4):605-611.
[Content Brief]