CONTACT US
Home > Inhibitors/Agonists>Anti-infection>Bacterial> > Ofloxacin
82419-36-1-Ofloxacin Ofloxacin

Ofloxacin

For research use only. Not for therapeutic Use.

  • CAT Number: A000867
  • CAS Number: 82419-36-1
  • Molecular Formula: C18H20FN3O4
  • Molecular Weight: 361.40
  • Purity: ≥95%
Inquiry Now
Related Small Molecules: N-Desethyl amodiaquine-d5 dihydrochloride     PCI 29732     PARP-1-IN-2    
Research Areas: Antibiotic Resistance     Infection Disease Research    
Ofloxacin（Cat No.:A000867）is a broad-spectrum fluoroquinolone antibiotic effective against both Gram-positive and Gram-negative bacteria. It functions by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair, leading to cell death. Ofloxacin is commonly used to treat a variety of infections, including respiratory tract infections, urinary tract infections, skin infections, and certain types of gastrointestinal infections. Known for its high oral bioavailability, it provides a convenient treatment option in both outpatient and hospital settings. Its broad efficacy makes it a valuable choice in antibacterial therapy.

Catalog Number A000867
CAS Number 82419-36-1
Synonyms

Ofloxacin; 82419-36-1; Ofloxacine; Floxin; Tarivid; Oxaldin

Molecular Formula C18H20FN3O4
Purity ≥95%
Target Topoisomerase
Solubility Limited solubility
Storage -20°C
IUPAC Name 7-fluoro-2-methyl-6-(4-methylpiperazin-1-yl)-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
InChI InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChIKey GSDSWSVVBLHKDQ-UHFFFAOYSA-N
SMILES CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
Reference

1: El-Zahry MR, Lendl B. Structure elucidation and degradation kinetic study of
Ofloxacin using surface enhanced Raman spectroscopy. Spectrochim Acta A Mol
Biomol Spectrosc. 2017 Dec 5;193:63-70. doi: 10.1016/j.saa.2017.12.007. [Epub
ahead of print] PubMed PMID: 29223055. <br />
2: Watson N, Gomez Serrano M, Selvadurai D. Topical ofloxacin use in G6PD
deficiency – safe or unsafe? Clin Otolaryngol. 2017 Dec 6. doi:
10.1111/coa.13043. [Epub ahead of print] PubMed PMID: 29210182. <br />
3: Lee H, Ahn S, Hwang NY, Jeon K, Kwon OJ, Huh HJ, Lee NY, Kim CK, Koh WJ.
Limited Effect of Later-generation Fluoroquinolones in the Treatment of
Ofloxacin-resistant and Moxifloxacin-susceptible Multidrug-resistant
Tuberculosis. Antimicrob Agents Chemother. 2017 Dec 4. pii: AAC.01784-17. doi:
10.1128/AAC.01784-17. [Epub ahead of print] PubMed PMID: 29203478. <br />
4: Kaur R, Kushwaha JP, Singh N. Electro-oxidation of Ofloxacin antibiotic by
dimensionally stable Ti/RuO(2) anode: Evaluation and mechanistic approach.
Chemosphere. 2017 Nov 16;193:685-694. doi: 10.1016/j.chemosphere.2017.11.065.
[Epub ahead of print] PubMed PMID: 29172159. <br />
5: Huang P, Ge C, Feng D, Yu H, Luo J, Li J, Strong PJ, Sarmah AK, Bolan NS, Wang
H. Effects of metal ions and pH on ofloxacin sorption to cassava residue-derived
biochar. Sci Total Environ. 2017 Oct 23. pii: S0048-9697(17)32888-7. doi:
10.1016/j.scitotenv.2017.10.177. [Epub ahead of print] PubMed PMID: 29074248. <br />
6: Bhattacharya A, Sharan R, Praharaj SK. High Dose Ofloxacin-induced Bimodal
Hallucinations in a 4 Years Old Child. Clin Psychopharmacol Neurosci. 2017 Nov
30;15(4):416-417. doi: 10.9758/cpn.2017.15.4.416. PubMed PMID: 29073756; PubMed
Central PMCID: PMC5678492. <br />
7: Jin H, Qi C, Zou Y, Kong Y, Ruan Z, Ding H, Xie X, Zhang J. Biochanin A
partially restores the activity of ofloxacin and ciprofloxacin against
topoisomerase IV mutation-associated fluoroquinolone-resistant Ureaplasma
species. J Med Microbiol. 2017 Nov;66(11):1545-1553. doi: 10.1099/jmm.0.000598.
Epub 2017 Oct 6. PubMed PMID: 28984242. <br />
8: Mirzajani R, Pourreza N, Burromandpiroze J. Fabrication of magnetic
Fe(3)O(4)@nSiO(2)@mSiO(2)-NH(2) core-shell mesoporous nanocomposite and its
application for highly efficient ultrasound assisted dispersive
μSPE-spectrofluorimetric detection of ofloxacin in urine and plasma samples.
Ultrason Sonochem. 2018 Jan;40(Pt A):101-112. doi:
10.1016/j.ultsonch.2017.06.027. Epub 2017 Jun 29. PubMed PMID: 28946397. <br />
9: Gouza A, Saoiabi S, El Karbane M, Masse S, Laurent G, Rami A, Saoiabi A,
Laghzizil A, Coradin T. Oil shale powders and their interactions with
ciprofloxacin, ofloxacin, and oxytetracycline antibiotics. Environ Sci Pollut Res
Int. 2017 Nov;24(33):25977-25985. doi: 10.1007/s11356-017-0100-5. Epub 2017 Sep
23. PubMed PMID: 28940003. <br />
10: Jin H, Tian X, Nie Y, Zhou Z, Yang C, Li Y, Lu L. Oxygen Vacancy Promoted
Heterogeneous Fenton-like Degradation of Ofloxacin at pH 3.2-9.0 by Cu
Substituted Magnetic Fe(3)O(4)@FeOOH Nanocomposite. Environ Sci Technol. 2017 Nov
7;51(21):12699-12706. doi: 10.1021/acs.est.7b04503. Epub 2017 Oct 17. PubMed
PMID: 28934546.

Request a Quote