For research use only. Not for therapeutic Use.
Highly specific inhibitor of lysine specific demethylase 1 (LSD1, also known as KDM1A, or H3K9 demethylase) (IC50, ~0.02 µM).
OG-L002 potently repressed herpes simplex virus (HSV) IE gene expression, genome replication, and reactivation from latency. It suppressed primary lytic infection of HSV in vivo in a mouse model. This highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles.
| Catalog Number | I033831 |
| CAS Number | 1357298-75-9 |
| Molecular Formula | C15H15NO.HCl |
| Purity | ≥95% |
| IUPAC Name | 3-[4-[(1R,2S)-2-aminocyclopropyl]phenyl]phenol;hydrochloride |
| InChI | InChI=1S/C15H15NO.ClH/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12;/h1-8,14-15,17H,9,16H2;1H/t14-,15+;/m1./s1 |
| SMILES | C1[C@@H]([C@H]1N)C2=CC=C(C=C2)C3=CC(=CC=C3)O.Cl |
| Reference | Y Liang et al. A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency. MBio. 2013, 4, e00558-12. Z Watson et al. Role of Polycomb Proteins in Regulating HSV-1 Latency. Viruses 2013, 5, 1740-1757. |
