For research use only. Not for therapeutic Use.
OGG1-IN-O8 (CAT: I011972) is a specific inhibitor of 8-Oxoguanine DNA Glycosylase-1 (OGG1). OGG1 is an enzyme involved in the base excision repair pathway, specifically targeting and removing the oxidative DNA lesion 8-oxoguanine from damaged DNA. By inhibiting OGG1, OGG1-IN-O8 prevents the enzymatic activity of OGG1, thereby impeding the repair of oxidative DNA damage. This inhibition can be utilized in research settings to study the role of OGG1 in DNA repair processes and investigate its potential implications in various disease conditions associated with oxidative stress and DNA damage.
| Catalog Number | I011972 |
| CAS Number | 350997-39-6 |
| Synonyms | OGG1-IN-O8; OGG1 IN O8; OGG1INO8; OGG1 Inhibitor O8;3,4-Dichloro-benzo[b]thiophene-2-carboxylic acid hydrazide |
| Molecular Formula | C9H6Cl2N2OS |
| Purity | ≥95% |
| Target | OGG! inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| IUPAC Name | 3,4-dichloro-1-benzothiophene-2-carbohydrazide |
| InChI | InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14) |
| InChIKey | HSSHUDKWJRJKPV-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C(=C1)Cl)C(=C(S2)C(=O)NN)Cl |
| Reference | </br>1: Donley N, Jaruga P, Coskun E, Dizdaroglu M, McCullough AK, Lloyd RS. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015 Oct 16;10(10):2334-43. doi: 10.1021/acschembio.5b00452. Epub 2015 Aug 7. PubMed PMID: 26218629; PubMed Central PMCID: PMC4894821.</br></br> |
